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Clinical Evidence Supporting Tirzepatide Use in Non-Diabetic Weight Loss The SURMOUNT-1 trial enrolled 2,539 non-diabetic adults with obesity and found that tirzepatide produced dose-dependent weight loss ranging from 15% at the 5 mg dose to 21% at the 15 mg dose, compared to 3% with placebo over 72 weeks

(3) non-human studies

The labeled side-effect profile is well-characterized: nausea, vomiting, diarrhea, constipation, abdominal pain, and headache are common, especially during dose escalation

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This is thought to affect angiogenic activity, fibroblast behavior, and collagen organization in tissue repair models