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Our results are clinically relevant and consistent with clinical reports that the secretory capacity of -cell was diminished in first-degree relatives of individuals with T2DM even before the onset of obesity and insulin resistance 32

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Surgery Without surgery, on average about 60% of patients will symptomatically remain the same and 20% will get worse

L., Rovers, M

Long-term hyperglycemia causes depressive behaviors in mice with hypoa ctive glutamatergic activity in the medial prefrontal cortex, which is not reversed by insulin treatment