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Sample D4, shown in green, was used as reference strain (MEcoli_ref_2) for all other experiments in this study

[6] The question of why NAD+ levels decline with age has been investigated in model organisms

Later studies, combining purified human proteins or human liver microsomes with specific inhibitors confirm the role of CYP2E1 in bioactivation of toxic levels of APAP, but also report involvement of CYP2A6 [31,32]

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