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10.1371/journal.pone.0160620 186 PasseriE.ElkhouryK.MorsinkM.BroersenK.LinderM.TamayolA.et al (2022)

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Its telling your brain youve eaten enough, while slowing gastric emptying and suppressing post-meal glucagon through the amylin system rather than the incretin system

It appears to influence multiple systems involved in tissue healing: 1

Journal of Neurology, Neurosurgery, and Psychiatry

In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight