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Treatment duration: 12 weeks

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In their study, four severely obese patients diagnosed with pathogenic heterozygous MC4R variants (2 adults and 2 adolescents) achieved a mean weight reduction of 5.9 kg following 16 weeks of liraglutide treatment, corresponding to a 5.8% reduction from their baseline body weight

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The researchers conclude that intestinal bacteria of meat eaters feed on L-carnitine to produce TMAO, which can clog arteries

It was approved for the treatment of type 2 diabetes in the United States in May 2022, and for the management of obesity in November 2023