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The output criterion was to observe anywhere between 3 and 100 pulses, where more than 55% of the pulses initiated prior to reaching the middle point of the sigmoid gradient (the point of maximal first derivative, as expected for adaptation to the gradient's first derivative)

doi: 10.1038/s42003-024-06534-6 27 NeelsJGGollentzCChinettiG

Because of such high demand , patients HAVE been able to obtain what they want

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These drugs can increase risk of serious infection and cancer (NIH 2013