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For all compounds, molecular descriptors including molecular weight, logP, topological polar surface area (tPSA), hydrogen bond donors/acceptors, rotatable bonds, aromaticity indices, and charge-related parameters were computed using QikProp from Maestro Desmond (Schrdinger Release 2024-3: QikProp, 2025)

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Drucker DJ (2018) Mechanisms of action and therapeutic application of glucagon-like peptide-1

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