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Glutathione-S-transferase-P1 I105V polymorphism and response to antenatal betamethasone in the prevention of respiratory distress syndrome

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GCLM interacts with GCLC, making the GCL holoenzyme kinetically more efficient in glutathione synthesis since GCLC has a very high Km for l-glutamate compared to when it is complexed with GCLM 32,33