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The human and animal-based clinical trials show that subjects have experienced benefits like longer life span, antioxidant effects, and timely circadian rhythms

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Mol Cell Biol 23(21):74487459 Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH (2011) Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

Many AOD9604 non-clinical studies showed no evidence of genetic damage or toxic effects

Practical timeline expectations For researchers who decide to proceed with a combined protocol despite the unknown risks, realistic timeline expectations help set appropriate milestones for evaluation