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Obesity is a global public health crisis, and while lifestyle intervention remains the first-line therapy, many adults require additional support

Josephs, M

COPD: J Chronic Obstr Pulm Dis

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We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling

Kemp M, Go Y-M, Jones DP