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Caffeine Whilst caffeine isnt a novel substance, not a supplement, it deserves a mention because Huberman is a big fan

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Semaglutide can cause GI discomfort that changes with dose and is usually easy to control with titration methods

Fluid normalization typically correlates with sustained weight reduction rather than immediate pharmacologic diuresis

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Town M, Jean G, Cherqui S, Attard M, Forestier L, Whitmore SA, Callen DF, Gribouval O, Broyer M, Bates GP, vant Hoff W, Antignac C (1998) A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis