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Diabetes 2011;60:2588-97.PubMedPMC 39

The GH spike from CJC-1295, and its subsequent IGF-1 release, is more associated with hypertrophy (growth of existing cells)

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[DOI] [PubMed] [Google Scholar] 67.Krarup T, Holst JJ

Itching during GLP-1 therapy usually results from dehydration (reduced fluid intake due to nausea), rapid fat mobilization triggering inflammatory responses, or changes in diet and skin flora

At higher doses, more TMA is produced than the body's enzymes can fully oxidize, and the excess is cleared through breath, sweat, and urine producing the odor some users report