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Codelivery of antigens and adjuvant in polymeric nanoparticles coated with native parasite membranes induces protective mucosal immunity against Giardia lamblia

Published Tuesday in The New England Journal of Medicine, the Phase 3 TRANSCEND trial confirms that setmelanotide (IMCIVREE) produced a placebo-adjusted BMI reduction of nearly 20 percentage points over 52 weeks, establishing peer-reviewed evidence for the first and only FDA-approved drug targeting acquired hypothalamic obesity

The good news is that this effect typically improves within weeks as your body adapts, and several practical strategies can reduce its severity while you adjust

Depending on the patients response and glycemic control, the dose may be further increased

Now, the not-so-fun part: dehydration

Most Indians cannot access or afford these medications