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This dual approach can lead to more substantial weight loss and improved glycemic control compared to either medication alone

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180,181 Because SHBG binds to sex hormones and reduces their bioavailability, decreased SHBG levels lead to increased androgen signaling and is closely associated with both ovarian dysfunction and metabolic disturbance

SUSTAIN 6 was primarily focused on cardiovascular outcomes but also observed weight management as a secondary outcome

The WHO panel recommended their use for patients with diabetes who also have cardiovascular disease, chronic kidney disease, or obesity

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