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SM significantly induced -endorphin expression and activated p38 mitogen-activated protein kinase signaling in the spinal dorsal horn and primary microglia

The medications, which were initially intended to treat Type 2 diabetes, have seen a 700% increase in usage between 2019 and 2023 in the United States due to their powerful weight-loss effects as they mimic the natural GLP-1 hormone that regulates blood sugar and appetite, while also boosting insulin production, slow digestion and having the patient feel full longer

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doi: 10.1161/CIRCRESAHA.116.306206