When GSSG accumulates excessively due to dysfunctional SLC33A1 activity, this inhibits enzymes required for proper disulfide bond formation and quality control, resulting in protein misfolding and aggregation within the ER
Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione (GSH), oxidized glutathione (GSSG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P4), tumor necrosis factor-alpha (TNF-), caspases (casp), lactoperoxidase (LPO), oxysuccinimide (OSI), total oxidant status (TOS), deoxyribonucleic acid (DNA)
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These new compounds might provide more options to those suffering low ovarian reserve due to age, disease, or other causes
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Rat spatial data are available at Source data are provided with this paper