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doi: 10.1212/01.wnl.0000259522.49388.53 72 GrafJ.LeussinkV

The porcine pi-class enzyme pGTSP1-1 was the first GST to have its structure determined, and it is representative of other members of the cytosolic GST superfamily, which contain a thioredoxin-like N -terminal domain as well as a C -terminal domain consisting of alpha helices

In animal studies, this change inhibits detoxification, depletes glutathione levels, and increases inflammation

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Additionally, it is well described that a substantial increase in fibrosis and steatosis frequently leads to fatal cirrhosis and even hepatocellular carcinoma in humans [1]

The area under this main peak, expressed as a percentage of the total area of all peaks detected, represents the peptide's purity