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In vitro assessments of cytotoxicity and cellular uptake revealed the efficient release of DOX in hypoxia environments upon azo bond cleavage, leading to higher cytotoxicity than in normal conditions

[25] This appraisal is useful context for understanding how similar agents are evaluated in the UK, but it does not apply directly to retatrutide, which remains unlicensed

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2023 Mar 1;16(3):dmm049769