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An imbalance of these substances, whether it be an excess or deficiency of neurotransmitters, can result in abnormalities within the signaling system of the brain, ultimately leading to the onset and development of depression (Kim et al., 2019)

Zhao Y, Zhang L, Qiao Y, Zhou X, Wu G, Wang L, et al

224 Additionally, eicosapentaenoic acid ethyl ester enhances the antioxidant capacity of UC rats by promoting the expression of the SIRT1 protein, thereby activating the Nrf2 pathway and inhibiting the expression of NF-B to regulate downstream inflammatory cytokines

Monthly maintenance sessions are recommended following the attainment of results

Cleveland Clinic makes a similar point in a 2026 explainer: IV vitamin therapy can be useful in specific situations, but is often oversold

General monitoring