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In the clinical trials of retatrutide, dose escalation was paused or reduced when participants experienced intolerable side effects, most commonly gastrointestinal symptoms such as nausea, vomiting, or diarrhoea

This combination could be a powerful tool for individuals struggling with weight loss

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If a higher semaglutide dose is clinically appropriate for weight loss, your provider may recommend Wegovy (approved up to 7.2 mg weekly) or compounded semaglutide

Some limitations apply

Patients with a history of severe hypoglycemia, hypoglycemia unawareness, or long-standing diabetes with autonomic neuropathy require particularly careful assessment