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Consistently, we found that administration of CA, an endogenous FXR agonist, could not only significantly attenuate the T3-induced elevation of GLP-1 and insulin levels but also attenuate the glucose-lowering effect of T3 in MMI mice (Fig

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In mammalian cells, the UPR is a highly conserved cellular signaling response, which is composed of three ER transmembrane proteins: inositol-requiring kinase 1 (IRE1), double-stranded RNA-dependent protein kinase-like ER kinase (PERK) and activating transcription factor-6 (ATF6)