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These can include: Nausea Diarrhea or constipation Mild stomach pain Fatigue Most of these symptoms are temporary and occur during the first few weeks or when your dose is increased

Because tirzepatide activates two receptors (GLP-1 and GIP) while semaglutide activates one (GLP-1 only), the shape of this dose-response relationship may differ between the medications

PubMed Khavinson VK

The far-ranging data set also includes trials involving insulin

a Favor SGLT2 inhibitors or a GLP-1 receptor agonist over placebo

While their clinical benefits are clear, their high costs are reshaping employer health plans in 2025 and creating pressure on pharmacy benefit budgets