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The combination matters because GHK-Cu (glycyl-L-histidyl-L-lysine copper) cannot permeate intact human skin

When your skin is constantly irritated, red, inflamed, or sensitive to everything you applyits often a sign of a damaged skin barrier

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Research published in the Journal of Biological Chemistry found that GHK-Cu "significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration" tested, but this relationship becomes more complex at higher levels

Its available in supplement form, and also in organ meats (such as liver) and brewers yeast