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Nonetheless, studies conducted in living organisms indicate that their concentrations are often insufficient to effectively traverse the bloodbrain barrier, limiting their bioavailability, stability, and dissolution at the intended brain sites

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Collingridge GL, Lester RA (1989) Excitatory amino acid receptors in the vertebrate central nervous system

These effects occur in a minority of users and rarely require stopping

10.1038/nature10554 188

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