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The results were impressive, with a 2.53x increase in free testosterone and a 2.15x increase in total testosterone, and other biomarkers maintaining evidence of good health

GLP-1 medications slow gastric emptying significantly, meaning food and stomach acid stay in the stomach longer

Source: Coskun et al., The Lancet 2022 Phase 2 Results Phase 2 -- Obesity (NEJM 2023) NCT04881760 | Published: New England Journal of Medicine , 2023 (Jastreboff AM, et al.) This was the landmark Phase 2 trial that put retatrutide on the map

GLP-1 agonists help to control your blood sugar , but people taking them also tend to lose weight

The needles

Another key point: stopping therapy leads to regain in most people, which argues for getting to and staying at an effective maintenance dose rather than hovering at subtherapeutic levels