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Tirzepatide is a dual agonist that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, while other medications in this class activate only GLP-1 receptors
Study F: TRESIBA Administered at the Same Time Each Day in Insulin Nave Adult Patients as an Add-on to One or More of the Following Oral Agents: Metformin, Sulfonylurea, Glinides or Alpha-Glucosidase Inhibitors The efficacy of TRESIBA was evaluated in a 26-week randomized, open-label, multicenter trial in Asia in 435 insulin nave patients with type 2 diabetes mellitus inadequately controlled on one or more oral antidiabetic agents (OADs) at baseline
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However, long-term administration of GCs at high doses is frequently associated with severe adverse effects, in particular, metabolic disorders and atrophic effects, including musculoskeletal side effects (glucocorticoid-induced osteoporosis (GIO), osteonecrosis, myopathy), disorders of carbohydrate and fat metabolism (diabetes mellitus, dyslipidemia, obesity), gastrointestinal, cardiovascular effects (Fig