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: 2016 UpToDate Summary adjunct therapy to reduce Hb A1c levels in patients with Type 2 diabetes who are inadequately controlled by other hypoglycemic agents

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These benefits appear to result from weight loss, improved glycemic control, modest blood pressure reduction, and potential direct cardioprotective effectsnot from metabolic rate enhancement

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Compounded versions of semaglutide and tirzepatide represent one alternative pathway that some patients explore when brand-name coverage is unavailable