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They are approved only for type 2 diabetes and, in specific formulations, for chronic weight management in patients meeting strict criteria
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Of note, they licensed a CLDN18 ADC (EO-3021) to Elevation Oncology ($27 million upfront, up to $1.148 billion in milestones) and a Nectin 4 ADC (SYS6002) to Corbus ($7.5 million upfront, $680 million in milesstones) YS2302018 is a preclinical small molecule lipoprotein(a) disruptor that was licensed to AstraZeneca
Mayorov AV, Cai M, Palmer ES, et al
Therefore, in individuals with shorter life expectancy or those at higher risk of hypoglycemia, less stringent HbA1c targets may be appropriate to minimize treatment burden and avoid hypoglycemia