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The recent meta-analyses indicated that in patients with high TMAO plasma level, the incidence of major adverse cardiovascular events was significantly higher compared with patients with low TMAO levels [67], and that all-cause mortality increased by 7.6% per each 10 mol/L increment of TMAO [68]

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3 Pharmacological mechanisms of tirzepatide and its applications in metabolic diseases Tirzepatide is a novel dual receptor agonist targeting both GLP-1 and GIP receptors

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