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The first enzyme, glutamatecysteine ligase (GCL) formerly called -glutamylcysteine synthase (GCS) is the rate-limiting enzyme
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1 Introduction Riboflavin (vitamin B2) is a water-soluble micronutrient essential for cellular energy metabolism, antioxidant defense, and neuronal function ( Over the past decade, increasing evidence has revealed that disturbances in riboflavin metabolism, transport, or utilization contribute to a spectrum of neurological disorders
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doi: 10.1053/j.gastro.2020.08.016 36 JohnsonMOWolfMMMaddenMZAndrejevaGSugiuraAContrerasDCet al