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It also normalized intestinal permeability, restored cortical BDNF to control levels and significantly improved behavioral parameters in PTSD-model male mice, confirming probiotic efficacy via MGBA modulation

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In the phase 2 trial of cagrilintide 2.4 mg co-administered with semaglutide 2.4 mg (CagriSema) in people with type 2 diabetes, the combination improved glycemic control and body weight relative to semaglutide alone, consistent with amylin adding a postprandial glucose-lowering contribution on top of GLP-1 action