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Despite these limitations, the findings that the effects of oral semaglutide on cardiovascular outcomes were comparable in those with or without baseline or incident SGLT2i are noteworthy, because SOUL is now the GLP-1 RA trial with the highest penetrance of overall concurrent SGLT2i use, and this question remains an important one in clinical practice

Semaglutide comes in two delivery forms: oral tablets and injectable solutions

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Another thing that is very common with GSH and the addition of B-Vits and Methyl donors is an imbalance of sulfation products causing a transient (but scary) sulfite reaction after an IV