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Cysteine oxidation produces disulfide bonds, sulfenic acid, sulfinic acid, and ultimately sulfonic acid

Sexual Function Research Wessells et al

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Even though the pharmaceutical industry appears to have largely withdrawn its interest in pursuing the H3R as an anti-obesity target (189), work endures to optimize H3R ligands and explore their potential to influence food intake and body weight, and H3R antagonists/inverse agonists continue to be proposed for the treatment of obesity (190, 191)

Pharmacological agents such as GLP-1 RAs and dual glucose-dependent insulinotropic polypeptide/GLP-1 agonists bypass these defects by directly stimulating the hypothalamic satiety centers and enhancing insulin sensitivity [9,10]