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10-12 In patients with severe to very severe COPD, diminished HRQoL has been shown to persist for up to 12 months after an acute symptomatic exacerbation

The reduction of dehydroascorbate may be non-enzymatic or catalysed by proteins with dehydroascorbate reductase activity, such as glutathione S -transferase omega 1 or glutaredoxins

H., Woodford N., George R

16 Although accumulating evidence demonstrated success in controlling TACE-related pain could reduce opioid analgesic use and improve patient quality of life, there is still considerable heterogeneity in drug selection and the associated duration of action and route of administration

Neurology 57 , 14221427 (2001)

It is not targeting a single symptom but rather restoring the underlying cellular machinery