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The shortage resulted from demand exceeding fill-finish capacity at Novo Nordisk's Clayton, North Carolina facility

For acne, improvements often start within weeks after beginning treatment

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Major diabetes organizations, including the American Diabetes Association, recommend considering GLP-1 agonists in patients on metformin who have not reached their treatment targets, particularly those with cardiovascular disease or significant weight loss needs

Tirzepatide-related fatigue likely results from multiple factors including caloric restriction and rapid weight loss, gastrointestinal side effects reducing nutritional intake and causing dehydration, blood glucose fluctuations, and sleep disturbances related to dietary changes or gastrointestinal discomfort

The most common side effects of Ozempic are gastrointestinal, including nausea, vomiting, diarrhoea, abdominal pain, and constipation