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The local GI argument is the strongest case for capsules, but it is rarely explained correctly If BPC-157 is degraded locally in the gut lumen and acts on GI epithelial receptors before degradation, then high oral bioavailability is not required for a GI-local effect

Patients might notice a decline in mental clarity, difficulty concentrating, or uncharacteristic mood changes

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Conclusion Apart from the poor aqueous solubility of CsA, poor pre-corneal retention of marketed CsA eye drops is a key concern that limits the efficient management of DED