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In contrast, the authors found no increased risk with Rybelsus tablets or tirzepatide

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The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year

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Older adults (75 and older): Aging bodies may process drugs more slowly and are more sensitive to side effects

This story originally appeared in the May 4, 2026 issue of Woman's World