There was no significant disparity in adverse reactions among the different preparations of GLP-1RA, among which the most common were gastrointestinal reactions, which mainly manifested as nausea, vomiting, and diarrhea
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Note: GLP-1 RAs differ in their dosing frequency (daily or weekly, depending on the agent)
Importantly, a substantial number of patients had multiple reasons noted for stopping (21%), underscoring the complexity of real-world medication use and the challenges patients face when using these therapies
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Skin laxity As fat deflates, the overlying skin can appear loose because collagen and elastin networks were already declining with age, which may accelerate the appearance of sagging