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A generic formulation that achieves the same clinical performance as the branded product through a different polymer matrix, a different excipient system, or a different device mechanism does not infringe the branded delivery patents

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Place the patch, adhesive side down, onto your chosen, prepped skin site

The rationale is theoretical and based on mitochondrial effects

Heatmap generation Heatmap indicating transcript abundance and expression pattern was generated using the HEATMAP hierarchical clustering web tool ( The log2 fold-change values of relative expression levels (the 2 (Ct) value) were used to construct the heatmap