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The phase 2 diabetes trial (published in The Lancet) used the same general titration framework but with more intensive metabolic monitoring

TGR5-mediated bile acid sensing controls glucose homeostasis

Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes-2023

Insulin resistance drives both type 2 diabetes and cardiovascular disease through overlapping mechanisms

The random-effects model, based on the DerSimonian and Laird methods, was chosen under the assumption that the true effect size may vary across studies due to clinical and methodological differences

& Lawley, S