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Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven

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In simple terms, it activates one hunger-regulating pathway while blocking another, which researchers believe may produce durable weight loss without a plateau

State officials cited concerns about addiction, lack of regulation, and potential health risks as key reasons for the ban