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Ex vivo , ASHMI significantly and dose-dependently reduced tracheal restriction to acetylcholine, which was abolished by cyclooxygenase inhibition and prostaglandin E2 receptors, EP2/EP4 receptor blockade [105]

Obesity and Fat Metabolism Clinical trials involving 300 obese patients demonstrated tripled Body-weight change compared to placebo over 12 weeks

It improves insulin sensitivity. Glucose and insulin measurements changed in diet-induced obese mice

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PMCID: PMC8770374

Research trials typically used cream-based formulations at this concentration range applied for 812 weeks before significant results were measured