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These astrocytic end-feet may also present a swollen phenotype under certain pathological conditions [46, 57]

Peak weight loss per the STEP trial trajectory occurs at approximately 6068 weeks of continuous use at maintenance dose

Heider K., Eustis S

doi: 10.1007/S00253-023-12656-4

Additional symptoms of the genetic disorder may become apparent from early childhood: a heightened interest in food and easy weight gain underdeveloped genitals sleep conditions and disorders, including sleep apnea (disrupted breathing while sleeping) and excessive daytime sleepiness language delays and speech problems cognitive issues and learning disabilities behavioral problems, such as stubbornness, temper tantrums, and obsessive-compulsive behaviors like skin picking decreased pain sensitivity thick saliva and tooth issues

Overall, these effects help reduce calorie intake, leading to weight loss