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If you take aspirin, NSAIDs, or blood thinners, discuss timing with your provider

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[2] Tramadol is conditionally recommended for treatment of osteoarthritis of the hand, knee, or hip in patients who may have contraindications to NSAIDs, find other therapies ineffective, or have no available surgical options

Rosti, L., Nardini, A., Bettinelli, M

Factors including baseline metabolic rate, diet adherence, physical activity level, and genetic predisposition to GLP-1 receptor sensitivity influence the speed and magnitude of your individual response