The clinical success of dual and triple incretin agonists has validated the concept that engaging multiple complementary pathways within a single molecular framework can yield superior efficacy without proportionally increasing toxicity (Finan et al., 2016)
One weekly injection may be all you need, but when it comes to optimizing the value of GLP-1s, thats not all there is to it
While this helps with appetite changes, it can also trigger nausea via central nervous system pathways, particularly in the early weeks of treatment
The most well-known, so-called skinny shots are semaglutide and tirzepatide
Sepesi B, Schmidt HE, Lada M, Correa A, Walsh GL, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Ajani JA, Watson TJ, Swisher SG , Low DE, Hofstetter WL
2012;4:a011254