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Although GRKs display kinase activity, GRKs can also interact with intracellular proteins and modulate downstream signaling pathways in a kinase activity-dependent and -independent manner

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doi: 10.1038/sj.mn.7800204

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Clinical research on the FDA-approved branded versions of these active ingredients includes the STEP-1 trial, which demonstrated mean weight reduction of approximately 14.9% with semaglutide over 68 weeks, and the SURMOUNT-1 trial, which showed tirzepatide achieving 1622.5% weight reduction over 72 weeks