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FDA-APPROVED INDICATIONS Injection Weight loss (adults) As an adjunct to diet and exercise for weight loss in adults with a BMI 30 or 27 in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes, dyslipidemia) [STEP 1 study] Adult BMI calculator Weight loss (children 12 years old) As an adjunct to a reduced-calorie diet and increased physical activity in pediatric patients aged 12 years and older with an initial BMI at the 95th percentile or greater for age and sex

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His/His SULT1A1 eliminates the sulfation backup for catechol estrogens, increasing quinone formation risk in parallel with slow COMT

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