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Potential skin-related effects that may occur include: Hypersensitivity reactions , which may manifest as rash, pruritus (itching), or urticaria (hives) Localised skin irritation Rare cases of more serious hypersensitivity reactions including angioedema (swelling of deeper skin layers, particularly around the face and throat) Some patients anecdotally report a general increase in skin sensitivity , which may manifest as heightened reactivity to environmental factors, cosmetics, or skincare products

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