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Inhibition of key ferroptosis regulators like acyl coenzyme ACSL4, GPX4, and Nrf2 may lead to unintended consequences, including disruptions to cellular homeostasis, thereby posing potential risks to therapeutic safety

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arrived at by two different design philosophies

These insights significantly advance our understanding of how E3 ligases are used in plants to translate hormone perception into genetic adaptations

Additionally, we performed quantitative amino acid profiling of individuals from konzo-prone regions which suggests a deficiency in cystine, the precursor for the antioxidant glutathione, which is required by GPx3 to effectively remove ROS from circulation 22