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Kaempferol increased the cell viability, improved MMP, inhibited the opening of mitochondrial permeability transition pores, reduced the levels of oxidative stress and apoptosis, increased the expressions of Bcl-2 and mitochondrial cytochrome c, and decreased the expressions of Bax and cytoplasmic cytochrome via SIRT 1/PGC-1 signaling pathway [165]

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Peptide-spectra matches were then grouped based on protein ID, excluding peptides with summed reporter ion intensities for the WT channels 0.5, non-unique or non-tryptic peptide sequences

This peptide-based mechanism slows gastric emptying, enhances insulin secretion only when blood glucose rises, and reduces hunger signals through the vagus nervea gentler, more metabolically targeted approach than amphetamine-class drugs